Determination of the Thickness of Tablet Coating by Near-Infrared Spectroscopy

Autoři

  • J. Muselík Department of Pharmaceutics,
  • K. Krejčová Department of Pharmaceutics,
  • M. Rabišková Department of Pharmaceutics,
  • A. Bartošíková Department of Pharmaceutics,
  • M. Dračková Institute of Milk Hygiene and Technology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
  • L. Vorlová Institute of Milk Hygiene and Technology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic

Abstrakt

The aim of this study was to develop a fast and reliable method for determination of tablet coating thickness. Tablets were coated with polymeric Pharmacoat® 606 in a laboratory coater. The coating thickness was measured by near-IR absorption of the coating material using calibration. The calibration and validation results afforded the following parameters: determination coefficient R2 > 0.97, the number of factors 6 and the standard error of cross-validation 5.4 μm at the coating thickness 25125 μm. The obtained results confirmed suitability of the method for evaluation of coating quality.

Stahování

Publikováno

15.02.2010

Jak citovat

Muselík, J., Krejčová, K., Rabišková, M., Bartošíková, A., Dračková, M., & Vorlová, L. (2010). Determination of the Thickness of Tablet Coating by Near-Infrared Spectroscopy. Chemické Listy, 104(1). Získáno z http://www-.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/1418

Číslo

Vol 104 No 1 (2010)

Sekce

Články